一、基本信息：

姓 名：袁宝

职 称：博士，教授，博士研究生导师

所在部门：实验动物学系

研究方向：人类疾病动物模型制备，动物繁殖调控，实验动物质量控制

办公电话：0431-87836536

电子邮件：yuanbao1982@163.com，yuan_bao@jlu.edu.cn

二、学习与工作经历：

2019.10 ~ 今： 拼搏体育客户端，拼搏体育客户端，教授

2015.10 ~ 2019.09：拼搏体育客户端，拼搏体育客户端，副教授

2015.08 ~ 2017.01：韩国忠北国立大学，农业与生命学院，访问学者

2008.10 ~ 2015.09：拼搏体育客户端，拼搏体育客户端，讲师

2004.07~ 2008.09：拼搏体育客户端，实验动物中心，助教

三、主要教学工作（承担的本科生、研究生课程）

主要承担本科生及研究生《比较医学概论》,《实验动物方法学》,《实验动物伦理福利》，《动物繁殖生物技术》等课程的教学任务。

四、主要科研项目

1. 国家自然基金面上项目，lncRNA-M7s1—miR-7通过Raf/MEK/ERK信号通路调控牛腺垂体FSH分泌机制的研究（31872349），2019.01-2022.12，经费60万元。负责人。

2. 国家自然基金青年基金，miR-181家族对牛FSHβ基因转录后调控及FSH分泌作用机制的研究（31501954），2016.01-2018.12，经费24万元。负责人。

3. 科技部国家科技支撑，实验用猫病原微生物检测技术研究与应用（2015BAI07B02-09），2015.03-2017.12，经费60万元，负责人。

4. 科技部国家科技支撑，公畜种用性能早期评定与预测（2011BAD19B04-2）2011.01-2014.12，经费42万元，负责人。

5. 吉林省科研条件项目，实验动物良种繁育，2013.01-2015.12，经费60万元，负责人。

6. 吉林省实验动物专项，实验用猫病毒快速检测新技术研究与应用，2017.01-2018.12，经费 20万元，负责人

五、主要科研成果（著作、专利、论文）

通讯作者文章列表

1. Han DX, Sun XL, Wang CJ, Yu ZW, Zheng Y, Huang YJ, Wang WH, Jiang H, Gao Y,Yuan B（通讯）, Zhang JB. Differentially expressed lncRNA-m433s1 regulates FSH secretion by functioning as a miRNA sponge in male rat anterior pituitary cellsdagger. Biol Reprod 2019, 101(2): 416-425.

2. D.X. Han, C.J. Wang, X.L. Sun, J.B. Liu, H. Jiang, Y. Gao, C.Z. Chen,Yuan B（通讯）, J.B. Zhang, Identification of circular RNAs in the immature and mature rat anterior pituitary, J Endocrinol, 240 (2019) 393-402.

3. Zhang Z, Wang W, Liu JB, Wang Y, Hao JD, Huang YJ, Gao Y, Jiang H,Yuan B（通讯）, Zhang JB. ssc-miR-204 regulates porcine preadipocyte differentiation and apoptosis by targeting TGFBR1 and TGFBR2. J Cell Biochem 2019.

4. C.J. Wang, H.X. Guo, D.X. Han, Z.W. Yu, Y. Zheng, H. Jiang, Y. Gao,Yuan B（通讯）, J.B. Zhang, Pituitary tissue-specific miR-7a-5p regulates FSH expression in rat anterior adenohypophyseal cells, PeerJ, 7 (2019) e6458.

5. Yu ZW, Gao W, Feng XY, Zhang JY, Guo HX, Wang CJ, Chen J, Hu JP, Ren WZ,Yuan B（通讯）. Roles of differential expression of miR-543-5p in GH regulation in rat anterior pituitary cells and GH3 cells. PLoS One 2019, 14(9): e0222340.

6. Z. Zhang, Y. Gao, M.Q. Xu, C.J. Wang, X.H. Fu, J.B. Liu, D.X. Han, H. Jiang,Yuan B（通讯）, J.B. Zhang, miR-181a regulate porcine preadipocyte differentiation by targeting TGFBR1, Gene 681 (2018) 45-51.

7. Z. Zhang, C.Z. Chen, M.Q. Xu, L.Q. Zhang, J.B. Liu, Y. Gao, H. Jiang,Yuan B（通讯）, J.B. Zhang, MiR-31 and miR-143 affect steroid hormone synthesis and inhibit cell apoptosis in bovine granulosa cells through FSHR, Theriogenology 123 (2018) 45-53.

8. M.J. Zhang, W.Z. Ren, X.J. Sun, Y. Liu, K.W. Liu, Z.H. Ji, W. Gao,Yuan B（通讯）, GeneChip analysis of resistant Mycobacterium tuberculosis with previously treated tuberculosis in Changchun, BMC Infect Dis 18(1) (2018) 234.

9. M.Q. Xu, H. Jiang, L.Q. Zhang, X.L. Sun, D. Luo, Y. Fu, Y. Gao,Yuan B（通讯）, J.B. Zhang, MiR-29b affects the secretion of PROG and promotes the proliferation of bovine corpus luteum cells, PLoS One 13(4) (2018) e0195562.

10. X.L. Sun, H. Jiang, D.X. Han, Y. Fu, J.B. Liu, Y. Gao, S.M. Hu,Yuan B（通讯）, J.B. Zhang, The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment, PLoS One 13(9) (2018) e0204524.

11. D.X. Han, Y. Xiao, C.J. Wang, H. Jiang, Y. Gao,Yuan B（通讯）, J.B. Zhang, Regulation of FSH expression by differentially expressed miR-186-5p in rat anterior adenohypophyseal cells, PLoS One 13(3) (2018) e0194300.

12. Y. Fu, H. Jiang, J.B. Liu, X.L. Sun, Z. Zhang, S. Li, Y. Gao,Yuan B（通讯）, J.B. Zhang, Genome-wide analysis of circular RNAs in bovine cumulus cells treated with BMP15 and GDF9, Sci Rep 8(1) (2018) 7944.

13. Han DX, Sun XL, Fu Y, Wang CJ, Liu JB, Jiang H, Gao Y, Chen CZ,Yuan B（通讯）, Zhang JB. Identification of long non-coding RNAs in the immature and mature rat anterior pituitary. Scientific Reports. 2017; 7.:

14. Ji ZH, Chen J, Gao W, Zhang JY, Quan FS, Hu JP,Yuan B（通讯）, Ren WZ. Cutaneous transcriptome analysis in NIH hairless mice. Plos One. 2017; 12.:

15. Han DX, Sun XL, Xu MQ, Chen CZ, Jiang H, Gao Y,Yuan B（通讯）, Zhang JB. Roles of differential expression of microRNA-21-3p and microRNA-433 in FSH regulation in rat anterior pituitary cells. Oncotarget. 2017; 8: 36553-65.:

16. Ji ZH, Ren WZ, Gao W, Hao Y, Gao W, Chen J, Quan FS, Hu JP,Yuan B（通讯）. Analyzing the innate immunity of NIH hairless mice and the impact of gut microbial polymorphisms on Listeria monocytogenes infection. Oncotarget. 2017; 8: 106222-32.:

17. Fu Y, Xu JJ, Sun XL, Jiang H, Han DX, Liu C, Gao Y,Yuan B（通讯）, Zhang JB. Function of JARID2 in bovines during early embryonic development. Peerj. 2017; 5.

第1作者文章列表

1. Yuan B, Liang S, Jin YX, Zhang MJ, Zhang JB, Kim NH. Toxic effects of atrazine on porcine oocytes and possible mechanisms of action. Plos One. 2017; 12.:

2. Yuan B, Liang S, Kwon JW, Jin YX, Park SH, Wang HY, Sun TY, Zhang JB, Kim NH. The Role of Glucose Metabolism on Porcine Oocyte Cytoplasmic Maturation and Its Possible Mechanisms. Plos One. 2016; 11.

3. Yuan B, Liang S, Jin YX, Kwon JW, Zhang JB, Kim NH. Progesterone influences cytoplasmic maturation in porcine oocytes developing in vitro. Peerj. 2016; 4.:

4. Yuan B, Han DX, Dai LS, Gao Y, Ding Y, Yu XF, Chen J, Jiang H, Chen CZ, Zhang JB. A comprehensive expression profile of micrornas in rat's pituitary. International Journal of Clinical and Experimental Medicine. 2015; 8: 13289-95.:

六、奖励与荣誉

1. 优质肉牛良种扩繁与生产技术体系的建立与应用，吉林省科学技术进步奖，二等奖（2/12），2019.11，吉林省科学技术厅。
   

2. 优质肉牛规范化生产技术体系研究与集成示范，吉林省科学技术进步奖，一等奖（10/15），2012.09，吉林省科学技术厅。